000913基金净值_持有股票交易增值税

Xinyi Wang,  Guangqiang Sun,  […] Meiyu Geng  Abstract Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression. Using AD mouse models, we discovered that, during AD progression, the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine, which stimulates the differentiation and proliferation of pro-inflammatory T helper … Continue reading

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Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study

Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study   Stefanos Tyrovolas1,2,3,  Demosthenes Panagiotakos3,4,  Ekavi Georgousopoulou3,4,5,  Christina Chrysohoou6,  Dimitrios Tousoulis6,  Josep Maria Haro1,2,7,  Christos Pitsavos6 Abstract Background Skeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old. Methods ATTICA is a prospective, population-based study that recruited 3042 adults without … Continue reading

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Chinese – Beware early retirement!

Higher life expectancy and rapidly aging populations have led to the introduction of pension programs in developing countries in the last two decades. Using the introduction of a new public policy in China, we estimate the effects of pension benefits on individual cognition, measured by episodic memory and intact mental status, among individuals ages 60 and above. We find large and significant negative effects of the provision of pension benefits on cognitive functioning among the elderly. Continue reading

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Sex differences in cardiometabolic disorders

Sex differences in cardiometabolic disorders Eva Gerdts & Vera Regitz-Zagrosek Nature Medicine (2019) Abstract The prevalence of cardiometabolic disorders in both women and men has increased worldwide and is linked to a rise in obesity and obesity-associated associated clustering of other cardiometabolic risk factors such as hypertension, impaired glucose regulation and dyslipidemia. However, the predominance of common types of cardiometabolic disorders such as heart failure, atrial fibrillation and ischemic heart disease is sex specific, and our identification of these and the underlying mechanisms is only … Continue reading

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During Deep Sleep, the Brain Does Housekeeping

(Reuters Health) – During deep sleep, the brain may be tidying up the detritus that accumulates during a hard day of thinking, a recent study suggests. Continue reading

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

REVIEW| VOLUME 179, ISSUE 2, P312-339, OCTOBER 03, 2019 Purchase Subscribe Save Share Reprints Request Alzheimer Disease: An Update on Pathobiology and Treatment Strategies Justin M. Long David M. Holtzman Published:September 26, 2019DOI:https://doi.org/10.1016/j.cell.2019.09.001 References Article Info Related Articles Comments Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary neuropathologic criteria for AD diagnosis. However, a number of recent fundamental discoveries highlight important … Continue reading

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A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial

A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial Heather M. Francis , Richard J. Stevenson, Jaime R. Chambers, Dolly Gupta, Brooklyn Newey, Chai K. Lim Published: October 9, 2019 https://doi.org/10.1371/journal.pone.0222768 Article Authors Metrics Comments Media Coverage Abstract Introduction Methods Results Discussion Supporting information Acknowledgments References Reader Comments (0) Media Coverage (3) Figures Abstract There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy … Continue reading

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Depressionen: Entzündete Seele

Depressionen: Entzündete Seele Die Hinweise mehren sich, dass chronische Entzündungen Auslöser für Depressionen sein können. Von Max Lebsanft 12. Juli 2017, 17:01 UhrEditiert am 17. Juli 2017, 7:17 UhrDIE ZEIT Nr. 29/2017, 13. Juli 2017190 Kommentare https://www.zeit.de/2017/29/depressionen-chronische-entzuendungen-psychologie-forschung?utm_campaign=ref&utm_source=twitter_zonaudev_int&utm_medium=sm&wt_zmc=sm.int.zonaudev.twitter.ref.zeitde.redpost.link.sf&utm_content=zeitde_redpost+_link_sf

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Alzheimer’s Drug Linked to Potentially Serious Muscle Condition

Alzheimer’s Drug Linked to Potentially Serious Muscle Condition Megan Brooks September 19, 2019 The Alzheimer’s drug donepezil (multiple brands) is associated with a twofold higher risk for hospital admission for rhabdomyolysis, a rare but potentially life-threatening condition in which muscle cells break down. It can lead to kidney damage. Results of a population-based study showed that use of donepezil was associated a significantly higher risk for rhabdomyolysis compared to other cholinesterase inhibitors, although the investigators note that the absolute risk was small. “Clinicians should have an index … Continue reading

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Walking Speed at Early Ages Tied to Cognitive Health

Walking Speed at Early Ages Tied to Cognitive Health — Slowest walkers showed deteriorating cognitive performance from age 3 to adulthood by Judy George, Senior Staff Writer, MedPage Today October 11, 2019 share to facebook share to twitter share to linkedin email article Gait speed at age 45 was a marker of cognitive and physical aging, a longitudinal cohort study showed. Slow gait at age 45 was tied to accelerated biological aging across multiple organ systems and reduced brain volume and cortical thickness, according to … Continue reading

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Young Adults’ Wallet Woes May Harm the Brain in Midlife

Young Adults’ Wallet Woes May Harm the Brain in Midlife -Findings emphasize how specific socioeconomic changes may negatively affect brain health by Zeena Nackerdien PhD, CME Writer, MedPage Today October 12, 2019 share to facebook share to twitter share to linkedin email article CME INFORMATIONMust be read prior to engaging in activity Study Authors: Leslie Grasset, M. Maria Glymour, et al.; Joel Salinas Target Audience and Goal Statement: Neurologists, family physicians, primary care physicians The goal of this study was to explore the relationship between … Continue reading

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Fasting as a Therapy in Neurological Disease

Fasting as a Therapy in Neurological Disease by Matthew C.L. Phillips Department of Neurology, Waikato Hospital, Hamilton 3204, New Zealand Nutrients 2019, 11(10), 2501; https://doi.org/10.3390/nu11102501 Received: 22 September 2019 / Revised: 12 October 2019 / Accepted: 15 October 2019 / Published: 17 October 2019 View Full-Text Download PDF Browse Figure Abstract Fasting is deeply entrenched in evolution, yet its potential applications to today’s most common, disabling neurological diseases remain relatively unexplored. Fasting induces an altered metabolic state that optimizes neuron bioenergetics, plasticity, and resilience in … Continue reading

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